query-9478b29e70b58181639308cd94e5a3a7

rq turtle/ttl

Given a variant ID, find drugs that may target a protein in the same pathway SELECT ?gene ?geneLabel ?pathway ?pathwayLabel ?pathwayProtein ?pathwayProteinLabel ?drug ?drugLabel WHERE { values ?hgvsid {"NC_000007.13:g.140453136A>T"} # currently basing on HGVS ID because we don't have dbsnp IDs yet ?variant wdt:P3331 ?hgvsid . ?variant wdt:P3433 ?gene . ?gene wdt:P688 ?protein .

?pathway wdt:P527 ?protein . ?pathway wdt:P31 wd:Q4915012 . ?pathway wdt:P527 ?pathwayProtein . ?pathwayProtein wdt:P31 wd:Q8054 . ?pathwayProtein wdt:P129 ?drug . SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } }

Use at

PREFIX wikibase: <http://wikiba.se/ontology#>
PREFIX wdt: <http://www.wikidata.org/prop/direct/>
PREFIX wd: <http://www.wikidata.org/entity/>
PREFIX bd: <http://www.bigdata.com/rdf#>
# Given a variant ID, find drugs that may target a protein in the same pathway
SELECT ?gene ?geneLabel ?pathway ?pathwayLabel ?pathwayProtein ?pathwayProteinLabel ?drug ?drugLabel WHERE {
  values ?hgvsid {"NC_000007.13:g.140453136A>T"}  # currently basing on HGVS ID because we don't have dbsnp IDs yet
  ?variant wdt:P3331 ?hgvsid .
  ?variant wdt:P3433 ?gene .
  ?gene wdt:P688 ?protein .

  ?pathway wdt:P527* ?protein .
  ?pathway wdt:P31 wd:Q4915012 .
  ?pathway wdt:P527* ?pathwayProtein .
  ?pathwayProtein wdt:P31 wd:Q8054 .
  ?pathwayProtein wdt:P129 ?drug .
  SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . }
}

Query found at

graph TD classDef projected fill:lightgreen; classDef literal fill:orange; classDef iri fill:yellow; v7("?drug"):::projected v3("?gene"):::projected v1("?hgvsid") v5("?pathway"):::projected v6("?pathwayProtein"):::projected v4("?protein") v2("?variant") c10(["bd:serviceParam"]):::iri c6(["wd:Q4915012"]):::iri c7(["wd:Q8054"]):::iri c12(["en"]):::literal bind0[/VALUES ?hgvsid/] bind0-->v1 bind00(["NC_000007.13:g.140453136A>T"]) bind00 --> bind0 v2 --"wdt:P3331"--> v1 v2 --"wdt:P3433"--> v3 v3 --"wdt:P688"--> v4 v5 --"wdt:P527"--> v4 v5 --"wdt:P31"--> c6 v5 --"wdt:P527"--> v6 v6 --"wdt:P31"--> c7 v6 --"wdt:P129"--> v7 subgraph s1["http://wikiba.se/ontology#label"] style s1 stroke-width:4px; c10 --"wikibase:language"--> c12 end