query-03eb380863663ab0e68de6efe0b42996

rq turtle/ttl

cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000 cases where a drug physically interacts with the product of gene known to be genetically associated a disease

these cases may show opportunities to repurpose a drug for a new disease

See http://database.oxfordjournals.org/content/2016/baw083.long and

http://drug-repurposing.nationwidechildrens.org/search

an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival

https://jamia.oxfordjournals.org/content/22/1/179

currently set up to find drugs for cancers that target genes related to cell proliferation

adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them

SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel WHERE { ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA) ?disease wdt:P2293 ?gene . # genetic association between disease and gene ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..) ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes): #cell proliferation wd:Q14818032 (Current example) #apoptosis wd:Q14599311

#uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)

#?disease wdt:P2176 ?drug . # disease is treated by a drug SERVICE wikibase:label { bd:serviceParam wikibase:language "en" . } } LIMIT 1000

Use at

PREFIX wikibase: <http://wikiba.se/ontology#>
PREFIX wdt: <http://www.wikidata.org/prop/direct/>
PREFIX wd: <http://www.wikidata.org/entity/>
PREFIX bd: <http://www.bigdata.com/rdf#>
#cases where a drug physically interacts with the product of gene known to be genetically associated a disease
#these cases may show opportunities to repurpose a drug for a new disease
#See http://database.oxfordjournals.org/content/2016/baw083.long and
#http://drug-repurposing.nationwidechildrens.org/search
#an example that was recently validated involved a new link between Metformin wd:Q19484 and cancer survival
#https://jamia.oxfordjournals.org/content/22/1/179
#currently set up to find drugs for cancers that target genes related to cell proliferation
#adapt by changing constraints (e.g. to 'heart disease' Q190805) or removing them
SELECT ?drugLabel ?geneLabel ?biological_processLabel ?diseaseLabel
WHERE {
  ?drug wdt:P129 ?gene_product . # drug interacts with a gene_product
  ?gene wdt:P688 ?gene_product . # gene_product (usually a protein) is a product of a gene (a region of DNA)
  ?disease wdt:P2293 ?gene .     # genetic association between disease and gene
  ?disease wdt:P279* wd:Q12078 . # limit to cancers wd:Q12078 (the * operator runs up a transitive relation..)
  ?gene_product wdt:P682 ?biological_process . #add information about the GO biological processes that the gene is related to

   ?biological_process (wdt:P361|wdt:P279)* wd:Q189101 . # chain down subclass/part-of
   #Change the last statement (wd:Q14818032) to limit to genes related to certain biological processes (and their sub-processes):
      #cell proliferation wd:Q14818032 (Current example)
                #apoptosis wd:Q14599311

    #uncomment the next line to find a subset of the known true positives (there are not a lot of them in here yet; will lead to 4 drugs if biological process is cell proliferation 2018-12-17)
  #?disease wdt:P2176 ?drug . # disease is treated by a drug
    SERVICE wikibase:label {
        bd:serviceParam wikibase:language "en" .
  }
}
LIMIT 1000

Query found at

graph TD classDef projected fill:lightgreen; classDef literal fill:orange; classDef iri fill:yellow; v5("?biological_process") v4("?disease") v1("?drug") v3("?gene") v2("?gene_product") c5(["wd:Q12078"]):::iri c10(["bd:serviceParam"]):::iri c8(["wd:Q189101"]):::iri c12(["en"]):::literal v1 --"wdt:P129"--> v2 v3 --"wdt:P688"--> v2 v4 --"wdt:P2293"--> v3 v4 --"wdt:P279"--> c5 v2 --"wdt:P682"--> v5 subgraph union0[" Union "] subgraph union0l[" "] style union0l fill:#abf,stroke-dasharray: 3 3; v5 --"wdt:P279"--> c8 end subgraph union0r[" "] style union0r fill:#abf,stroke-dasharray: 3 3; v5 --"wdt:P361"--> c8 end union0r <== or ==> union0l end subgraph s1["http://wikiba.se/ontology#label"] style s1 stroke-width:4px; c10 --"wikibase:language"--> c12 end